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Als 1925 erstmals Symptome einer psychischen Erkrankung auftraten, wurde sie von der Universitäts-Nervenklinik Tübingen aufgenommen und drei Jahre lang behandelt, bis sie 1928 in die Privatheilanstalt Kennenburg in Esslingen überwiesen wurde. Nach dem Tod des Vaters 1930 übernahm ihre Schwester Anna Bach die Fürsorge für Charlotte, musste sie aber 1931 in die kostengünstigere staatliche Anstalt Winnental verlegen lassen. Am 24. Juni 1940 wurde Charlotte Steiner in die Tötungsanstalt Grafeneck transportiert und am selben Tag in der Gaskammer ermordet. 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